You can explore the Chemistry IA on hydrolysis of aspirin to salicylic acid. Similar to synthesis of aspirin the hydrolysis is also a good choice of chemistry Internal Assessment. Aspirin is acetylsalicylic acid shortly known as ASA. It is a medicine for reducing pain, fever, or inflammation. Aspirin shortly after a heart attack so that they can reduce the risk of death.
Want to learn how to hydrolyse aspirin and form salicylic acid? This step-by-step guide provides a detailed explanation of the process, so you can practice with confidence.
Chemistry IA on Hydrolysis of aspirin into salicylic acid is a simple but important process for those wanting to form the necessary acid for medical purposes. This guide will provide an overview of the key steps involved, from gathering the materials to the actual hydrolysis reaction.
Gather Reagents.
Before beginning the hydrolysis process, you will need to gather all of the necessary materials. For this experiment, you will need aspirin tablets, distilled water, a beaker, sodium hydroxide solution or pellets (NaOH), and a Bunsen burner.
Measure and Dissolve Aspirin in Water.
Once you have assembled all the necessary materials and equipment, begin the hydrolysis process by measuring out 1.0g of aspirin in a small beaker and then adding 10 mL of distilled water. Using a Bunsen burner, heat the mixture until the aspirin has dissolved completely and allow it to cool down before continuing.
Add Appropriate Amount of Acetic Acid to Solution.
After the aspirin has dissolved and cooled, carefully measure out a small amount of acetic acid based on the amount of aspirin used. For example, if you used 1.0g of aspirin, add 0.2mL of acetic acid to the mixture. Once the correct amount is added, stir the solution until it has become a consistent color throughout – usually light yellow or clear in appearance.
Add Bath of Ice-Water to Solution and Wait for Reaction Time Set Point.
When the acetic acid has been properly mixed in with the aspirin, it’s time to add a bath of ice-water. Start by adding water until it has reached 1/2 the volume of your test tube. Next, add a few ice cubes to the bath and wait for the reaction training set point – usually around 45F. This can take anywhere from 15 minutes to an hour depending on level of reactant concentration left in solution. Once the temperature reaches 45F, proceed with hydrolysis step.
Filter Solution, Adding Sodium Hydroxide if Necessary, and Extract Salicylic Acid in Separate Container or Beaker.
Now it’s time to filter the solution by passing the mixture through a funnel and layer of filter paper. As you do this, make sure you collect the insoluble material in a separate container or beaker. Finally, add sodium hydroxide to neutralize the acetic acid that remains and extract your final salicylic acid product into another container or beaker. Congratulations! You have successfully hydrolyzed aspirin!
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